文献资料 > 红斑狼疮
Linear chronic discoid lupus erythematosus following the lines of Blaschko2014.06.23
沿Blaschko线分布的线状慢性盘状红斑狼疮
红斑狼疮(LE)是一种炎症性自身免疫性疾病,具有不同侵犯部位的临床表现,从皮肤到全身系统。狼疮分为三大类:系统性红斑狼疮(SLE)、亚急性皮肤红斑狼疮(SCLE)、慢性皮肤红斑狼疮(CCLE)。后者被细分成其它疾病,包括盘状红斑狼疮(DLE),以红色萎缩性、角化过度...
Comedonic lupus: a rare presentation of discoid lupus erythematosus2014.06.03
痤疮样狼疮:盘状红斑狼疮一种罕见的临床表现
慢性皮肤型盘状红斑狼疮(CCDLE)或盘状红斑狼疮(DLE)是一种罕见的慢性自身免疫性皮肤病,也是红斑狼疮(LE)中最常见的临床类型。其病程缓慢,为紫外线辐射、寒冷和药物等因素所诱发因素。DLE是通过组织病理检查确诊。不常见的临床表现,如痤疮样狼疮,可与其他疾病相...
Serology of Lupus Erythematosus: Correlation between Immunopathological Features and Clinical Aspects2014.05.19
红斑狼疮血清学与免疫病理特征和临床表现之间的相关性研究
系统性红斑狼疮(SLE)是一种自身免疫性疾病,以大量异常产生自身抗体异构群为特征。尽管已知SLE自身抗体存在60多年了,但是目前仍然需要进一步研究以了解这些自身抗体的发病机制、诊断以及预后的意义。ds-DNA抗体对于SLE的诊断很有帮助,可以用来监测疾病的活动,并且与...
Genome-Wide DNA Methylation Analysis of Systemic Lupus Erythematosus Reveals Persistent Hypomethylation of Interferon Genes and Compositional Changes to CD4+ T-cell Populations2014.03.31
全基因组DNA的甲基化分析发现系统性红斑狼疮的患者干扰素基因持续性低甲基化以及CD4+T细胞群主要转化
系统性红斑狼疮(SLE)是一种与已知遗传因素、表观因素和环境危险因素有关的自身免疫性疾病。为了评估SLE中DNA甲基化的作用,我们收集了49例SLE患者和58名对照组的CD4 + T细胞、CD19+ B细胞和CD14+单核细胞,并应用Illumina甲基化450基因芯片对全基因组DNA甲基化进行分析...
Expression of interleukin-17 is correlated with interferon-αexpression in cutaneous lesions of lupus erythematosus2014.03.31
红斑狼疮皮损处白介素-17的表达与干扰素-α表达有关
研究背景: 据报道I型干扰素(IFN)在皮肤型红斑狼疮(CLE)和系统性红斑狼疮(SLE)的发展中具有重要的作用。CD4+T细胞的一个新的亚型——T辅助(Th)17细胞,也在自身免疫性疾病的发展中发挥作用。 Aim. Toinvestigate expression of interleukin(IL)-17 and IFN-a...
Systemic lupus erythematosus associated with moyamoya syndrome: a case report and literature review2014.03.31
与烟雾综合征相关的系统性红斑狼疮:一则病例报告和文献综述
烟雾综合征(MMS)是一种罕见的慢性渐进性脑血管闭塞性疾病,以双侧颈内动脉狭窄或闭塞为特征。我们报道了一例24岁伴有肾病综合征的女性患者,其活检显示为膜性肾病。确诊十个月后,患者突发右侧偏瘫和癫痫。七个月前,患者通过血管造影诊断出患有MMS并接受了去骨瓣减压...
The study of Cutaneous Lupus Erythematosus Disease Area and Severity Index in Indian patients with systemic lupus erythematosus2013.10.11
印度系统性红斑狼疮患者中皮肤型红斑狼疮病面积和严重度指数的研究
皮肤型红斑狼疮病面积和严重度指数(CLASI)是一种用来评价皮肤型红斑狼疮(CLE)引起的活动性和损毁的新的工具。印度在CLASI的数据上很缺乏。我们试图确定系统性红斑狼疮(SLE)患者中的CLE患者的特殊病灶处的CLASI的适用性,这些患者均来自印度三甲医院。在这项前瞻性...
Chilblain lupus erythematosus—a review of literature2013.10.11
冻疮样红斑狼疮-文献综述
冻疮红斑性狼疮( CHLE )是一种罕见的、慢性皮肤型红斑狼疮。本文报道了一些散发病例和两个患常染色体显性遗传CHLE病的家庭。在家族性CHLE中,患者体内有两个在TREX1中编码为3'-5'修复核酸外切酶1的错义突变。目前散发的CHLE的发病机制尚不清楚。高达20%的CHL...
Successful treatment of a novel generalized variant of canine discoid lupus erythematosus with oral hydroxychloroquine2013.10.09
Discoid lupus erythematosus (DLE) is a common canine autoimmune disease that usually manifests as a localized ulcerative and scarring nasal dermatitis. We report herein a generalized variant of canine DLE successfully treated with the antimalarial im...
线状皮肤型红斑狼疮六例2013.09.30
目的 探讨线状皮肤型红斑狼疮(LCLE)临床和组织病理学特点。方法 回顾分析6例LCLE的临床和病理学特点。结果 LCLE多单侧发病,表现为带状或线状分布的暗红斑,伴毛细血管增生扩张,部分黏着性鳞屑。组织病理学诊断依据为真皮浅、深丛细血管周围及毛囊、皮脂腺、汗...
Neonatal Lupus Erythematosus in Identical Twins, Showing Transient Bullous Lesions2013.09.30
One of identical twin girlswasbornwithulcersonher leg,and shortly after birth developed a flaccid blister on the leg. Subepidermal blister with vacuolar degeneration of basal cell layer and the heavy infiltration of mononuclear cells in the upper der...
Lupus Erythematosus Panniculitis in Children: Report of Three Cases and Review of Previously Reported Cases2013.09.30
Lupus erythematosus panniculitis (LEP) is a rare finding in children, with only 12 fully reported prior cases in the English literature. We describe three cases of LEP in children younger than 18 and compare them to previous cases reported in the lit...
Invariant natural killer T cells are enriched at the site of cutaneous inflammation in lupus erythematosus2013.09.30
Background: Systemic lupus erythematosus (SLE)is associated with a numerical and functional reduction of peripheral blood (PB) invariant natural killer T (iNKT) cells. Limited information exists on the role of iNKT cells in the pathogenesis of lu...
Neuropsychiatric systemic lupus erythematosus: Magnetic resonance imaging findings and correlation with clinical and immunological features2013.09.30
Neuropsychiatric (NP) syndromes are a major cause of morbidity and mortality in patients with systemic lupus 25 erythematosus (SLE). The aims of this work were to describe the brain abnormalities in a group ofSLE patients 26 during their first episod...
Nanogel-based delivery of mycophenolic acid ameliorates systemic lupus erythematosus in mice2013.09.30
The ability to selectively inactivate immune cells with immunosuppressants is a much sought-after modality for the treatment of systemic lupus erythematosus and autoimmunity in general. Here, we designed and tested a novel nanogel drug delivery vehic...
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