文献简介

出版社:Journal of Dermatology

作  者:Moon-Bum KIM, Gun-Wook KIM,1 Hyun-Je PARK

编  号:10.1111/j.1346-8138.2011.01223.x

关键字:calcineurin inhibitor | pimecrolimus | rosacea

年  份:2011   点击量:832

文献摘要

    Rosacea is a common inflammatory skin disorder; the pathogenesis is unclear. Various treatment options for rosacea are available, but most have limited effectiveness. The aim of this study was to investigate the efficacy and safety of 1% pimecrolimus cream for the treatment of rosacea. Thirty patients with rosacea were enrolled in this 4-week, single-center, open-label study of 1% pimecrolimus cream. Patients were instructed to apply the cream to their faces twice daily and were not permitted to use any other agents. Clinical efficacy was evaluated by a rosacea grading system using photographic documentation and amexameter. The 26 patients who completed the study experienced significantly reduced rosacea clinical scores from 9.65 ± 1.79 at baseline to 7.27 ± 2.11 at the end of treatment (P < 0.05). The mexameter-measured erythema index decreased significantly from 418.54 ± 89.56 at baseline to 382.23 ± 80.04 at week 4 (P < 0.05). The side-effects were mostly transient local irritations. The results of this study suggest that 1% pimecrolimus cream is an effective and well-tolerated treatment for patients with mild to moderate inflammatory rosacea.

   酒渣鼻是一种常见的炎症性皮肤病,发病机制尚不清楚。酒渣鼻的治疗可采用多种治疗方法,但绝大多数疗效有限。本研究的目的旨在调查1%吡美莫司乳膏治疗酒渣鼻的疗效和安全性。这是一项有关1%吡美莫司乳膏的研究,为期4周、单中心、非盲,共纳入30名酒渣鼻患者。要求患者每天脸部使用两次乳膏,并且不得使用其他任何药剂。采用照片文档和窄谱反射分光光度计的酒糟鼻分级系统对临床疗效进行评估。完成本项研究中26位患者的酒渣鼻临床评分得到了显著降低,临床评分从开始时的9.65±1.79下降为治疗后的7.27±2.11(P<0.05)。窄谱反射分光光度计测量的红斑指数从开始的418.54±89.56下降至第四周的382.23±80.04(P<0.05)副作用大多是短暂的局部刺激。这项研究的结果表明,对于轻度至中度炎症性酒渣鼻患者的治疗,1%吡美莫司乳膏是一种有效且耐受性良好的药物。