文献简介

出版社:European Review for Medical and Pharmacological Sciences

作  者:F. CANPOLAT, M. ERKOÇOĞLU*, H. TEZER**, C.N. KOCABAŞ*, B. KANDI

编  号:

关键字:Atopic dermatitis, Infants, Hydrocortisone ointment, Mupirocin, Staphylococcus.

年  份:2012   点击量:555

文献摘要

BACKGROUND:

 The skin of patients with atopic dermatitis (AD) is heavily colonized with Staphylococcus (S.) aureus, even at uninvolved sites. Toxins secreted by the majority of S. aureus on the skin behave as superantigens and can directly influence the disease activity, although clinical signs of bacterial superinfection might be absent.

研究背景:

特应性皮炎(AD)患者在皮损甚至非皮损处金黄色葡萄球菌(S.)的定植率很高。皮损处大多数金黄色葡萄球菌分泌的毒素表现为超抗原,并可以直接影响该疾病活动,尽管可能没有出现细菌二重感染的临床症状。

 

OBJECTIVES:

This study was conducted to compare the efficacy of hydrocortisone cream, combined with mupirocin or alone with emmolient ointment for the treatment of mild to moderate AD in infants between six months and two years of age.

研究目的:

本研究旨在对氢化可的松乳膏联用莫匹罗星或单独用药治疗六个月到两岁之间患度至中度AD的婴儿的疗效与emmolient软膏进行比较。

 

MATERIALS AND METHODS:

A total of 83 patients with mild to moderate AD were randomized to receive hydrocortisone, hydrocortisone+ mupirocin or emmolient ointment twice daily in one week and followed-up for 8 weeks, in a blind study. Efficacy evaluation made by SCORAD and eczema area and severity index (EASI) at baseline, day 7, and weeks 2, 4, and 8. Possible adverse events were recorded to evaluate safety.

材料和方法:

在双盲研究中,随机对83名轻度至中度AD患者施用氢化可的松、氢化可的松+莫匹罗星软及emmolient软膏,每天两次,持续一周,随访8周。采用SCORAD评分法(特应性皮炎评分指数)和EASI湿疹面积及严重度指数)为对第七天,第248周进行疗效评价。记录可能产生的不良反应来评估药物的安全性。

 

RESULTS:

At the end of study, 65% (17 of 26) of the patients were treated successfully with hydrocortisone ointment based on SCORAD and EASI scores. Also there was a significant improvement in patients combined with mupirocin ointment [74% (20 of 27)]. The percent improvement from baseline in EASI scores was also significantly greater in hydrocortisone and combined group compared with emmolient-treated patients (36%) (p = 0.0187, p = 0.012 respectively).

研究结果:

研究最后,根据SCORADEASI的评分,使用氢化可的松软膏的患者中65%(17/26)成功治愈。使用氢化可的松软膏与莫匹罗星软膏联合用药的患者也疗效显著[74%(20/27)]。在EASI评分上,氢化可的松与联合用药组对AD的改善百分率显著高于emmolient软膏(36%)(分别为p = 0.0187,p = 0.012)

 

CONCLUSIONS:

Monotherapy with hydrocortisone ointment is the main treatment in infants with mild to moderate AD and combination with mupirocin is safe and effective often needed because of possible Staphylococcus carriage.

研究结论

婴幼儿在患轻度至中度AD时,单独使用氢化可的松软膏是主要的治疗方法,联合莫匹罗星用药是安全和有效的,且这种联合用药往往是必要的,因为可能存在葡萄球菌。




F. CANPOLAT et al.Eur. Rev. Med. Pharmacol. Sci.2012; 16: 1989-1993