文献简介

出版社:Assocmedbras

作  者:Marta M. Shimizu等

编  号:r e v a s s o c m e d b r a s . 2 0 1 3;5 9(3):270–275

关键字:Atopic dermatitis; Epidemiology; Scoring Atopic Dermatitis; IgE

年  份:2013   点击量:869

提  供:http://www.sciencedirect.com/science/article/pii/S0104423013000535

文献摘要

Objective

Atopic dermatitis (AD) is a chronic inflammatory disease causing intense pruritus, and with typical clinical features. There are few epidemiological studies concerning AD in adults, as well as little information about its prognostic. The aim of this study was to evaluate the clinical and epidemiological course of adults with AD.

研究目的

特应性皮炎(AD)是一种伴剧烈瘙痒的慢性炎症性疾病,并有典型临床特征。关于成年AD患者的流行病学研究及其预后的资料少之又少。本研究旨在对成年AD患者的临床和流行病学进程进行评估。

Methods

80 patients aged above 18 years (mean age = 29 years) were selected (30 males and 50 females) and interviewed about hospitalization, systemic corticoid usage, age of AD onset, and personal and/or familial history of atopy. Disease severity was evaluated through the Scoring Atopic Dermatitis (SCORAD) tool. Laboratory examination included IgE serum levels and eosinophil blood count.

研究方法

80名(30名男性和50名女性)18岁以上(平均年龄=29岁)的患者入组,并对他们的住院情况、系统性皮质激素类药物的使用情况、AD发作的年龄以及个人和或家族史进行了回访。通过“特应性皮炎评分(SCORAD)”工具评估疾病的严重程度。实验室检查包括血清IgE水平和血嗜酸性粒细胞计数

Results

71 out of 80 patients referred association with respiratory symptoms (18 had asthma, 17 had rhinitis, and 36 had both conditions); nine out of 80 patients denied any respiratory disease. AD patients were divided in mild (n = 25), moderate (n = 30), and severe (n = 25); 56% had one or more hospitalizations due to AD. A positive association was found between IgE serum levels, eosinophil blood count, and disease severity.

研究结果

80名特应性皮炎患者中有71名伴呼吸道症状相关性(18名患有哮喘,17名患有鼻炎,36名两病共患)。另外9名患者称没有任何呼吸道疾病。AD患者被分成轻度(n = 25)、中度(n = 30)和重度(n = 25)56%的患者有过1次或多次因AD而住院治疗。我们发现血清IgE水平、血嗜酸性粒细胞计数与疾病的严重程度呈正相关。

Conclusion

Adult AD represents a clinical challenge that needs to be better characterized, since it can be misdiagnosed and interferes with the patient's social and personal life. The association of skin and respiratory atopic disease is frequent, and laboratory parameters such as circulating IgE levels and eosinophil blood count may be helpful to assess disease severity.

研究结论

因受患者社会和个人生活的影响,成年患者的AD容易被误诊,因此它仍是一个临床上的挑战,需要对其临床特征进行更好地描述。皮肤与呼吸道过敏性疾病密切关联;实验室检查诸如血循环的IgE水平、血嗜酸性粒细胞计数,有助于评估疾病的严重程度。