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关键字:生物膜;外阴阴道念珠菌病

年  份:2020   点击量:58

文献摘要 全文翻译

Candida species, including C. albicans, are part of the mucosal flora of most healthy women, and inhabit the gastrointestinal and genitourinary tracts. Under favourable conditions, they can colonize the vulvovaginal mucosa, giving rise to symptomatic vulvovaginal candidiasis (VVC). The mechanism by which Candida spp. produces inflammation is unknown. Both, the blastoconidia and the pseudohyphae are capable of destroying the vaginal epithelium by direct invasion. Although the symptoms are not always related to the fungal burden, in general, VVC is associated with a greater number of yeasts and pseudohyphae. Some years ago, C. albicans was the species most frequently involved in the different forms of VVC. However, infections by different species have emerged during the last two decades producing an increase in causative species of VVC such as C. glabrata, C. parapsilosis, C. krusei and C. tropicalis. Candida species are pathogenic organisms that have two forms of development: planktonic and biofilm. A biofilm is defined as a community of microorganisms attached to a surface and encompassed by an extracellular matrix. This form of presentation gives microorganisms greater resistance to antifungal agents.

念珠菌属,包括白色念珠菌,是大多数健康妇女粘膜菌群的一部分,定植在胃肠道和泌尿生殖道。在有利条件下,它们可以定植于外阴阴道粘膜,引发有症状的外阴阴道念珠菌病(VVC)。尚不清楚念珠菌产生炎症的机制。芽生孢子和假菌丝都能通过直接侵袭破坏阴道上皮。虽然症状并不一定与真菌负荷有关,但一般而言,VVC酵母菌和假菌丝增多有关。几年前,白色念珠菌是VVC中最常见的物种。然而,在过去的二十年中,已经出现了由不同菌群引起的感染,从而导致VVC致病物增加,例如光滑念珠菌、近平滑念珠菌、克鲁斯念珠菌和热带念珠菌。念珠菌具有两种发育形式的致病生物:浮游生物和生物膜。生物膜被定义为附着于表面并被细胞外基质包围的微生物群落。这种表现形式使微生物对抗真菌药物具有更强的抵抗力。