文献简介

出版社:JAMA

作  者:KonstantinDumann,MD;JenniferHaiduk,MD;MirjanaZiemer,MD

编  号:

关键字:线状;色素沉着;Moulin线状皮肤萎缩

年  份:2020   点击量:222

文献摘要 全文翻译

A woman in her late 20s presented with an asymptomatic hyperpigmentation on the right side of the trunk, right upper arm, and right leg, strictly following the lines of Blaschko (Figure, A and B). A slight atrophy of the hyperpigmented skin was palpable without any signs of induration.

患者女性,20余岁,躯干、右下臂和右腿可见沿Blaschko线分布的无症状色素沉着斑块(图A和B)。色素沉着皮肤轻度萎缩,未见任何硬结。

The first onset was in her childhood, at the age of 6 years, with a small hyperpigmentation on the right side of her lower chest remaining stable for years. In her early 20s the area of hyperpigmentation started to spread slowly over the above-mentioned areas and became more and more intense. Intravenous penicillin G therapy with 10 million units 3 times daily over 1 week combined with a UV-A1 phototherapy in 18 sessions with a maximum dose of 40J/cm2and a cumulative overall dose of 670J/cm2showed no effects. A punch biopsy was obtained (Figure, C and D).

患者首次发病在6岁时,右下胸部可见小块色素沉着,且多年来一直保持稳定。患者在20岁初期,色素过度沉着区域开始向上述区域缓慢扩散,且变得越来越严重。静脉注射青霉素G治疗,每日3次,持续1周以上,联合紫外线-A1光疗,共18次,最大剂量为40J/cm2,累计总剂量为670J/cm2,无任何效果,取钻孔活检标本(图C和D)。