文献简介

出版社:JAMA

作  者:Eric Duerr, BS; Jennifer Villaseñor-Park, MD, PhD; Lisa Grandinetti, MD

编  号:

关键字:朗格汉斯细胞组织细胞增多症

年  份:2014   点击量:119

文献摘要 全文翻译

A woman in her late 30s presented for evaluation and management of tender, reddish brown, slightly pruritic papules and plaques on the scalp, in the inframammary region, and in the perineum that had been present for approximately 1 year. Previous treatment with multiple courses of topical and systemic antifungals, topical and systemic corticosteroids, and oral antibiotics had failed. She reported pain, pruritus, and serous discharge associated with the plaques but denied any systemic symptoms. Her medical history was unremarkable, and she was not taking any medications at the time of presentation. Results of a physical examination revealed well-demarcated, moist, erythematosus plaques and erosions in the bilateral inframammary regions (Figure 1A) and the intertriginous regions of the groin and scattered excoriated papules on the scalp. A punch biopsy specimen of the plaque along the left inframammary region was sent for pathologic evaluation (Figure 1B-D).

患者女性,30余岁,因评估和管理头皮、乳房下区和会阴部1年前出现的疼痛、红棕色轻度瘙痒丘疹和斑块而就诊。先前治疗包括多次局部和全身抗真菌药物,局部和全身糖皮质激素和口服抗生素治疗,但治疗均失败。患者自述斑块处疼痛、瘙痒且伴有分泌物,但无全身症状。患者无显著病史,自述出现症状时,未服用任何药物。体格检查发现双侧乳房下区域(图1A)和腹股沟擦烂区域可见边界清楚的潮湿红斑和糜烂,皮头可见表皮脱落丘疹。从左侧乳房下区取穿刺活检标本,用于组织病理学评估(图1B-D)。