文献简介

出版社:JAMA

作  者:Aizuri Murad, MRCS, MRCP; Anne Fortune, MRCPI, FRCPath; Fergal J. Moloney, MD, MRCPI, FACD

编  号:

关键字:嗜中性外分泌性汗腺炎

年  份:2016   点击量:90

文献摘要 全文翻译

A woman in her 60s developed fever, rigors, periorbital swelling, and a painful perivulvar eruption, 7 days after her first cycle of cytarabine and daunorubicin hydrochloride for newly diagnosed acute myeloid leukemia (AML). She had a history of type 2 diabetes mellitus, hypothyroidism, and hypercholesterolemia. Her regular medications included metformin, insulin, rosuvastatin calcium, levothyroxine sodium, and aspirin. Examination revealed edematous labia and multiple perivulvar tender nodules on violaceous and indurated plaques sparing the vaginal mucosa and inguinal creases (Figure, A). She also had bilateral injected conjunctivae with periorbital swelling. A punch biopsy of the perivulvar lesions was performed for histopathologic analysis (Figure, B and C) and tissue culture.

患者女性,60余岁,第一次服用阿糖胞苷和盐酸柔红霉素治疗新诊断的急性髓样白血病(AML)7天后出现发热、寒颤、眶周水肿和外阴周围疼痛性皮疹。患者有2型糖尿病、甲状腺功能减退和高胆固醇血症病史。常规用药包括二甲双胍、胰岛素、瑞舒伐他汀钙、左旋甲状腺素钠和阿司匹林。检查显示阴唇水肿,外阴周围多发压痛结节,呈紫色和硬化斑块,未累及阴道粘膜和腹股沟皱褶区(图A)。患者还接受结膜伴肿胀眶周注射治疗。对外阴周围皮损行穿刺活检、组织病理学分析和组织培养(图B和C)。