文献简介

出版社:JAMA

作  者:Yang Lo, MD; Chien-Ho Chu, MD; Yi-An Chen, MD

编  号:

关键字:毛囊中心性硬化萎缩苔癣

年  份:2017   点击量:69

文献摘要 全文翻译

A woman in her 60s presented with numerous whitish papules on the back of more than 10 years’ duration. The lesions previously resolved with topical corticosteroids but flared soon after treatment discontinuation. Some papules became pruritic and extended to the waist and anterior trunk in the past month. No family history of similar lesions was recorded. Physical examination revealed multiple hypopigmented, flattopped papules on the back, waist, and inframammary area without genital involvement (Figure, A). Most lesions were folliculocentric under close inspection. Dermoscopy revealed central keratin plugs and some foci of structureless, whitish, and homogenous areas with surrounding erythema (Figure, B). The results of laboratory tests for antinuclear antibody and hyperglobulinemia were negative. A biopsy specimen was obtained from the back for histologic analysis (Figure, C).

患者女性,60余岁,因背部大量白色丘疹,持续10余年就诊。最初经局部皮质类固醇治疗后皮损消退,但停药后皮损很快复发。就诊前一个月,丘疹出现瘙痒感,并延伸至腰部和躯干前部。患者无类似皮损家族史。体格检查发现患者背部、腰部和乳房下区域可见多个色素减退、扁平丘疹,但未累及生殖器(图A)。仔细检查发现大多数皮损为毛囊中心性。皮肤镜检查显示中央角化栓和一些无结构、白色同质区域,周围可见红斑(图B)。抗核抗体和高球蛋白血症实验室检测结果均为阴性。从背部取活检标本行组织病理学分析(图C)。