文献简介

出版社:JAMA Dermatology

作  者:

编  号:Traci Pawlitschek, BA; Tamar Hajar, MD; Nicole Fett,MD, MSCE

关键字:硬化性粘液水肿;硬皮病

年  份:2019   点击量:157

文献摘要 全文翻译

A man in his 50s presented with dysphagia, arthritis, joint contractures, carpal tunnel syndrome, and infiltrated and redundant skin with sheets of 1- to 2-mm-wide waxy, firm, skin-colored papules. The patient first noticed papules on his forehead 1 year prior to presentation that spread to his face, trunk, and extremities. He had mild dysphagia and severe joint pain in his hands and wrists, with carpal tunnel of his right wrist. Additionally, his daily activities were impaired owing to decreased mobility. During clinical evaluation, he denied cough, shortness of breath, chest pain, Raynaud phenomenon, fevers, night sweats, weight loss, seizures, or confusion.

患者男性,50余岁,因吞咽困难、关节炎、关节挛缩、腕管综合征和浸润和冗余皮肤伴1至2 mm蜡质、坚硬皮肤色丘疹而就诊。1年前患者首次发现前额出现丘疹,并扩散至面部、躯干和四肢。患者有轻微吞咽困难,且手部、腕部严重关节痛,伴右手腕腕管综合征。此外,患者日常活动因行动能力下降而受损。在临床评估期间,患者否认出现咳嗽、呼吸短促、胸痛、雷诺现象、发烧、盗汗、体重减轻、癫痫发作或意识混乱。