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关键字:红斑狼疮;治疗

年  份:2018   点击量:84

文献摘要 全文翻译

The current treatment approach for systemic lupus erythematosus (SLE), as outlined in the recommendations by international medical associations including EUL AR and the ACR , is mostly eminence-based rather than evidence-based. However, knowledge on SLE is growing quickly , and such new advances need to be translated into clinical practice. Questions remain regarding the choice and timing of drug administration and tapering until withdrawal, which both can affect the balance between the control of disease activity and damage to organs triggered by long-standing and/or disproportionate immunosuppression. Currently , the treating physicians of patients with SLE are required to weigh the present with the future situation of their patients in an optimized balance between therapeutic harm and benefit. In this Review, the available therapeutic strategies and main challenges in the approach to SLE treatment are discussed. Remission and low disease activity are desirable therapeutic goals. Although the drug armamentarium for SLE has not expanded much in the past few decades, there are nonetheless opportunities to make better choices and explore combination therapies.

目前国际医师协会(包括EUL AR和ACR)推荐的系统性红斑狼疮(SLE)的治疗方法主要是基于名声而非基于证据。然而,关于SLE的知识正在迅速增长,这些新进展需要转化为临床实践。使用药物的选择和时机以及逐渐减量直至停药的问题仍然存在,这两者都可能影响疾病活动的控制和长期和/或过度免疫抑制引起的器官损害之间的平衡。目前,系统性红斑狼疮(SLE)患者的治疗医师需要在权衡治疗危害和疗效取得最佳平衡时,并权衡病情现状。本文综述了系统性红斑狼疮的可用治疗方法和面临的主要挑战。理想的治疗目标是疾病缓解和疾病低活动性。虽然过去几十年来SLE的药物治疗方法并未有很大发展,但仍然有机会作出更好的选择并探索联合疗法。