文献简介

出版社:

作  者:Sarah Mattessich, BS; Katalin Ferenczi, MD; Mona Shahriari, MD

编  号:

关键字:嗜中性皮脂腺炎

年  份:2018   点击量:42

文献摘要 全文翻译

A 21-year-old woman with no significant medical history presented with a 2-year history of asymptomatic, facial redness that flared in sunlight. She had been previously treated with doxycycline, 100 mg/d, and topical sulfacetamide with no effect. On examination, on the cheeks and nasal bridge there were multiple erythematous, annular plaques with focal areas of atrophy. Her medications included only an oral birth control pill. Serum chemical analyses and complete blood cell count showed no abnormalities, and anti-Ro, anti-La, and qualitative ANA antibodies were negative. A clinical diagnosis was made, and over the next 9 months, treatments with minocycline, desonide, topical metronidazole, 0.75%, cream and azelaic acid, 15%, were unsuccessful, and the plaques developed more scarring and atrophy (Figure, A). In addition, the patient began to develop a burning sensation in these areas. A punch biopsy specimen was obtained and submitted for histopathologic review (Figure, B and C).

患者女性,21岁,无显著病史,有2年无症状、面部发红病史,阳光照射下发作。患者曾接受多西环素100 mg / d和局部磺胺醋酰治疗,但效果不佳。检查发现,患者面颊和鼻梁处存在多个环状红斑且局部萎缩。患者仅口服过避孕药。血清化学分析和全血细胞计数未见异常,抗Ro、抗La和定性ANA抗体均呈阴性。临床诊断后9个月,患者接受米诺环素、地奈德、局部甲硝唑(0.75%)、乳膏和壬二酸(15%)治疗无效,且斑块发展为瘢痕且萎缩(图A)。此外,患者这些部位出现烧灼感。取钻孔活检标本,并进行组织病理学检查(图B和C)。