文献简介

出版社:JAMA Dermatology

作  者:Arianna F. Yanes, BA; Julia M. Mhlaba, MD; Xiaolong A. Zhou, MD, MSc

编  号:

关键字:嗜酸性脓疱性毛囊炎

年  份:2019   点击量:291

文献摘要 全文翻译

A Japanese man in his 50s presented with a 6-month history of worsening pruritic hand dermatitis that progressed to involve his face, trunk, upper extremities, and feet. He had emigrated from Japan more than 10 years earlier but had no history of recent travel. He took no medications, had no significant medical or surgical history, and denied personal and family history of atopy. While he worked as a biomedical researcher, he denied any caustic exposures. On physical examination, his face, trunk, upper extremities, palms, and soles were marked by 1- to 2-mm erythematous papules and pustules coalescing into large, partially indurated and polycyclic plaques with centrifugal extension and occasional central clearing(Figure, A and B). Treatment with potent topical corticosteroids was ineffective. Punch biopsies of lesions on the shoulder (Figure, C) and foot (Figure, D) were performed.

患者男性,日本人,50余岁,因手部6个月瘙痒性皮炎恶化而就诊,皮疹逐渐累及面部、躯干、上肢和腹部。患者十多年前从日本移居国外,但近期无旅游经历。他未服用任何药物,无明显病史或外科手术史,且否认了个人和家族性特应性病史。虽然患者是一名生物医学研究员,但他否认接触过任何腐蚀性物质。体格检查显示,患者面部、躯干、上肢、手掌和足底可见1~2mm红斑丘疹和脓疱聚集形成的大的,部分硬化的环状斑块,伴离心延伸和偶尔中心消退(图A和 B)。外用强效皮质类固醇治疗无效。取肩部(图C)和足部(图D)皮损行钻孔活检。