文献简介

出版社:JAMA Dermatology

作  者:Eric T. Stoopler, DMD, FDSRCS, FDSRCPS; Thomas P. Sollecito, DMD, FDS RCSEd; Faizan Alawi, DDS

编  号:

关键字:白色斑块;口腔毛状白斑

年  份:2018   点击量:169

文献摘要 全文翻译

An 80-year-old white woman presented with an asymptomatic white patch affecting the tongue of 1 month’s duration. She had a 15-year history of oral lichen planus (OLP) managed with betamethasone dipropionate, 0.05%, gel twice daily and clotrimazole troches, 10mg, 3 times daily as needed for symptomatic OLP flares. Medical history revealed stage 1A mycosis fungoides/cutaneous T-cell lymphoma affecting the right calf and left thigh managed primarily with halobetasol, 0.05%, cream owing to intolerance of narrowband UV-B therapy and mechlorethamine, 0.016%, gel. Immunosuppression or history of infectious diseases, including human immunodeficiency virus (HIV),was not reported. A 1.5 × 1.0-cm nonremovable white, plaque like lesion was observed on the left lateral tongue (Figure 1A). Biopsy specimens were obtained with a 3-mm punch instrument at 3 different sites, which demonstrated similar microscopic findings (Figure 1B and C).

患者女性,80岁,因舌部无症状白斑1个月就诊。患者有15年口腔扁平苔藓(OLP)病史,采用0.05%二丙酸倍他米松凝胶治疗,每日两次,必要时采用克霉唑,10mg,每日3次治疗突发性症状性OLP。病史显示患者有ⅠA 期蕈样肉芽肿/皮肤T细胞淋巴瘤病,累及右小腿和左大腿,主要外用0.05% 卤倍他索乳膏治疗,因患者窄谱 UVB 和0.016% 氮芥凝胶不耐受。患者无免疫抑制和感染病史(包括HIV感染)。左侧舌部可见一1.5×1.0 cm固定白斑皮损(图1A)。在3个不同部位行3mm钻孔活检取活检标本,结果与组织病理结果相似(图1B和C)。