文献简介

出版社:Clinical Immunology

作  者:

编  号:

关键字:荨麻疹;免疫调节疗法

年  份:2018   点击量:13

文献摘要 全文翻译

This paper summarizes and reviews the mechanisms of action and data concerning efficacy of recommended treatments as well as other treatments that have been tested, independently of the outcomes, in the management of chronic spontaneous urticaria. Due to the central role of mast cells, basophils and histamine in the pathophysiology of this disease, H1-antihistamines remain the first-line treatment. However, current knowledge about this complex disease, also recognizes an important role for T lymphocytes, B lymphocytes, and autoantibodies. Implications of these others mediators thus provide further targets for treatment. Indeed, agents previously used to treat other autoimmune and inflammatory diseases, have demonstrated efficacy in chronic spontaneous urticaria and are therefore potential therapeutic alternatives for antihistamine unresponsive patients.

本文总结和综述了慢性自发性荨麻疹的作用机制和推荐治疗方法和其他治疗方法的有效性数据,这些方法已独立于治疗结果进行了测试。由于肥大细胞、嗜碱性粒细胞和组胺在该病的病理生理学中的核心作用, H1抗组胺药仍然是一线疗法。然而,目前对该复杂疾病知识的了解也认识到T淋巴细胞、B淋巴细胞和自身抗体的重要作用。因此,这些其他介质的影响为治疗进一步提供了靶点。实际上,先前用于治疗其他自身免疫和炎性疾病的药物已经在慢性自发性荨麻疹中发挥作用,因此它是抗组胺药治疗无反应患者的潜在治疗选择。