文献简介

出版社:Am J Clin Dermatol

作  者:

编  号:

关键字:Acne Scarring

年  份:2018   点击量:302

文献摘要 全文翻译

Severe scarring has been reported in 30% of acne patients, although mild to moderate scarring has been reported in up to 95% of these patients. Acne scarring is often the result of delayed and/or inadequate medical treatment but can develop despite appropriate medical therapy. Collagen and other tissue damage, secondary to inflammation of acne, leads to permanent skin texture changes and fibrosis. Scars typically proceed through a cascade of wound healing phases: inflammation, granulation, and remodeling. Acne scarring is a therapeutic challenge as many treatments may be only partially effective, leading to patient disappointment and frustration. The detrimental effects of acne scarring are not limited to impaired cosmetic appearance. Rather, acne scarring has also been associated with depression and other mental health disorders, suicidal ideation, emotional debilitation, embarrassment, poor selfesteem, and general social impairment.

据报道,30%的痤疮患者出现严重瘢痕,虽然这些患者中高达95%为轻度至中度瘢痕。痤疮瘢痕通常是延迟和/或不充分治疗的结果,但尽管进行了适当的药物治疗,仍可能出现。继发于痤疮炎症的胶原蛋白和其他组织损伤导致永久性皮肤纹理改变和纤维化。瘢痕通常需经过一系列的伤口愈合阶段:炎症,肉芽期和重塑期。痤疮瘢痕治疗具有挑战,因为许多治疗仅部分有效,导致患者失望和沮丧。痤疮瘢痕的不利影响不限于外观受损。而且,痤疮瘢痕也与抑郁症和其他精神疾病、自杀倾向、情绪低落、尴尬、自尊心弱和一般社会障碍有关。