文献简介

出版社:国际皮肤性病学杂志

作  者:孙玉洁;陈敏

编  号:

关键字:银屑病;治疗应用;心血管疾病;糖尿病;肥胖症;肿瘤;高脂血症

年  份:2017   点击量:120

文献摘要

AbstractPsoriasis, as a chronic inflammatory skin disease involving immune mechanisms, is

linked to various systematic diseases, including metabolic syndrome, cancer and so onPsoriasis and its comorbidities tend to show influence on each other in the course of both diagnosis and treatmentIt is beneficial to understand the interaction between psoriasis and its comorbidities for comprehensive treatment and response evaluation in patientsFurthermore, it will bring people to reflect on medication strategiesThis review introduces how common systematic diseases, such as cardiovascular diseases, diabetes mellitus, hyperlipidemia and cancer, affect psoriasis and its treatment, and the effect of psoriasis and its treatment on these comorbidities will be also statedMain therapies of psoriasis, including traditional drugs, biologic agents, phototherapy and lifestyle improvement, may cause adverse reactions, induce or exacerbate systematic diseases, but may exert or expand therapeutic effects in systems other than the skin

【摘要】银屑病作为一种免疫机制参与介导的慢性炎症性皮肤病,与众多系统性疾病产生联系,包括代谢综合征、肿瘤等。银屑病与共患疾病在临床诊疗过程中常可相互影响,了解二者之间的相互作用有益于对患者进行综合治疗和疗效评估,同时也会带来对用药策略的思考。主要从常见的心血管疾病、糖尿病、高脂血症、肿瘤等方面介绍了这些系统性疾病的治疗如何影响银屑病及其治疗,并阐述银屑病及其治疗给共患疾病带来的影响。银屑病的主要治疗方法包括传统药物治疗、生物制剂、光疗以及生活方式的调整,治疗可能引起不良反应,诱发或加重系统性疾病,但也可能同时在皮肤外的其他系统发挥治疗作用,扩大治疗效应。