文献简介

出版社:国际皮肤性病学杂志

作  者:李志量;冯素英

编  号:

关键字:天疱疮;乙酰胆碱;桥粒芯糖蛋白质类

年  份:2017   点击量:143

文献摘要

AbstractPemphigus is an autoimmune disease induced by antoantibodies. Anti-desmoglein antibodies were previously thought to be the central part of the pathogenesis of pemphigus, but this view has been challenged by a series of research findings, including the discovery of many new antibodies. Some new theories have been raised to explain the occurrence of pemphigus, in which the acetylcholine system is essential to maintain keratinocyte adhesion and play an important role in the pathogenesis of pemphigus. ‘Basal cell shrinkage’ hypothesis and apoptolysis mechanism have also contributed to a better understanding of pemphigus pathogenesisThen findings have led to a substantial progress in steroid-sparing therapies of pemphigus, Which may improve the prognosis of pemphigus

【摘要】天疱疮是一种自身抗体引起的自身免疫性疾病,以往观点认为,抗桥粒芯蛋白抗体在天疱疮发病中处于核心地位,研究发现,疾病中的一些现象不能完全用桥粒芯抗体的理论解释,对这一观点提出补充,并发现了一系列新的天疱疮抗体,丰富了新的天疱疮发病理论。其中皮肤乙酰胆碱系统在介导角质形成细胞间黏附和天疱疮发病中具有重要作用,基底细胞收缩和松解凋亡理论也使得天疱疮的发病机制进一步完善。基于这些新的发病机制,天疱疮的非糖皮质激素治疗取得了一些进展,有望改善天疱疮患者预后。