文献简介

出版社:国际皮肤性病学杂志

作  者:邓维;张晓艳

编  号:

关键字:银屑病;结缔组织疾病;红斑狼疮,系统性;皮肌炎;硬皮病,系统性

年  份:2017   点击量:143

文献摘要

AbstractThe immunologic processes of psoriasis and connective tissue diseases are very complex, which involve a large number of regulatory mechanisms. In recent years, scholars have found that Th17 cells play an important role in the pathogenesis of psoriasis, systemic lupus erythematosus(SLE)and other diseases, and their common cytokines include interleukin(IL)-17, IL-21 and IL-23. Currently, the treatment of the two diseases usually includes glucocorticoids, immunosuppressive agents and biological agents targeting inflammatory pathways. In the treatment of coexisted psoriasis and connective tissue diseases, the use of glucocorticoids should be cautious. Treatment with immunosuppressive agents is only reported in some case reports, and lacks evidence from large sample-sized studies.
【摘要】银屑病和结缔组织病的免疫过程复杂,其中涉及到许多的调节相关机制。既往认为两种疾病的发病机制有明显区别,近年有学者发现,
Th17细胞在银屑病、系统性红斑狼疮等疾病的发病中起重要作用,其共同的细胞因子主要包括白细胞介素172123。目前治疗包括糖皮质激素、免疫抑制剂和针对炎症通道靶点治疗的生物制剂。针对两者并发的治疗,糖皮质激素的应用需谨慎,免疫抑制剂目前多为个案报道,缺乏大样本研究。