文献简介

出版社:国际皮肤性病学杂志

作  者:张瑜芬;王倩倩;拓江;项蕾红

编  号:

关键字:寻常痤疮;免疫;痤疮丙酸杆菌;炎症小体NLRP3

年  份:2017   点击量:172

文献摘要

【摘要】寻常痤疮是青春期常见的炎症性皮肤病,主要累及毛囊皮脂腺,其特点是在粉刺的基础上产生丘疹、脓疱、结节等损害。尽管痤疮治疗已取得较大的进展,但作为一种多炎性介质及细胞因子参与的疾病,对于痤疮在机体免疫系统方面的发病机制仍然知之甚少。在固有免疫中起重要作用的炎症小体是多种蛋白质组成的复合体,其激活后可导致促炎性细胞因子白细胞介素1β和白细胞介素18等的活化,影响痤疮病情变化。探讨炎症小体NLRP3与痤疮发病机制的研究,为痤疮治疗开辟新的思路。

AbstractAcne vulgaris, a common inflammatory skin disease in adolescence, mainly involves the pilosebaceous units and is characterized by papules, pustules and nodules besides comedones. The treatment of acne mainly includes topical and oral antibiotics and retinoids, and some new alternative therapies such as photodynamic therapyAlthough big progress has been made in the treatment of acne, as a kind of disease induced by multiple inflammatory mediators and cytokines, the immunological pathogenesis of acne still remains unclearInflammasomes are a multiprotein complex, and play an important role in innate immunityAfter activation of the inflammasomes, proinflammatory cytokines such as interleukin-1β (IL-1β)and IL-18 can be activated, followed by changes in acne condition. Reviewing studies on NLRP3 inflammasome and the pathogenesis of acne can provide new ideas for the treatment of acne