文献简介

出版社:国际皮肤性病学杂志

作  者:杨开颖;陈思源;吉毅

编  号:

关键字:血管瘤;婴儿;信号传导;血管内皮生长因子类;西罗莫司

年  份:2017   点击量:139

文献摘要

【摘要】婴儿血管瘤是婴幼儿期最常见的良性肿瘤,其发病机制尚未阐明。研究证实,异常的血管发生与血管生成是导致婴儿血管瘤增殖的病理学基础。多条关键的信号通路参与婴儿血管瘤的血管发生与血管生成的调控,包括血管内皮生长因子/血管内皮生长因子受体信号通路、Notch信号通路、血管紧张素/Tie信号通路、哺乳动物西罗莫司靶蛋白信号通路、肾素-血管紧张素系统信号通路以及β受体信号通路。这些信号通路相互作用,共同促进婴儿血管瘤的异常增殖。

AbstractInfantile hemangiomas are the most common benign tumor in infancy. Their pathogenesis has not been fully elucidated. Studies have demonstrated that aberrant angiogenesis and vascularization are the pathobiological basis for the growth of infantile hemangiomas. Multiple critical signaling pathways are involved in the regulation of angiogenesis and vascularization of infantile hemangiomas, including vascular endothelial growth factor(VEGF) /VEGF receptor signaling pathway, Notch signaling pathway, angiotensin/Tie signaling pathway, mammalian target of rapamycin complex (mTOR)signaling pathway, rennin-angiotensin system signaling pathway and β-adrenergic receptor signaling pathway. These signaling pathways interact with each other, and jointly promote the aberrant growth of infantile hemangiomas.