文献简介

出版社:JAMA Dermatology

作  者:Eric T. Stoopler, DMD; David Ojeda, DDS; Faizan Alawi, DDS

编  号:

关键字:Oral melanoacanthoma

年  份:2017   点击量:52

文献摘要 全文翻译

A white woman in her 50s presented to an oral medicine clinic for evaluation of asymptomatic pigmented lesions affecting the maxillary and mandibular gingiva of 6 years’ duration. The patient reported previous orolabial melanotic macules. Her medical history was significant for hypertension, hypercholesterolemia, asthma, and breast cancer. Medications included levalbuterol, nadolol, and cetirizine. Family medical history was significant for breast cancer and social history was unremarkable. Review of systems was positive for cutaneous ephelides. Physical examination revealed a 7 mm × 6 mm asymmetric, heterogeneously pigmented lesion without indurated borders on the gingival associated with the left maxillary central incisor tooth  (Figure, A). A lesion similar in clinical appearance, although smaller, was observed on the gingiva associated with the right mandibular first premolar tooth (Figure, B). Biopsy specimens were obtained with a 3 mm punch instrument from both lesions for routine histology which demonstrated similar microscopic findings (Figure, C and D).

患者白人女性,50余岁,因评估持续6年累及上颌和下颌牙龈的无症状色素皮损就诊口腔科。患者自述先前口唇部出现黑素斑。患者有显著高血压、高胆固醇血症、哮喘和乳腺癌病史。患者用药史包括左旋沙丁胺醇、纳多洛尔和西替利嗪。患者有显著乳腺癌家族史,而社会史无显著意义。系统检查示皮肤雀斑处阳性。体检发现一7 mm ×6 mm的非对称性、异基因色素性皮损,且左上颌中切牙牙龈处无硬化边界 (图A)。与右下颌第一前磨牙牙龈处发现类似皮损,虽然较小(图B)。采用3 mm钻孔活检机从两皮损处取活检标本用于常规组织学检查,结果显示与组织病理结果相似(图C和D)。