文献简介

出版社:Best Practice & Research Clinical Rheumatology

作  者:Natalia Vasquez-Canizares , Dawn Wahezi , Chaim Putterman

编  号:

关键字:systemic lupus erythematosus

年  份:2017   点击量:162

文献摘要 全文翻译

Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease characterized by autoantibodies directed against numerous self-nuclear antigens. Because of the heterogeneous nature of lupus, it has been challenging to identify markers that are sensitive and specific enough for its diagnosis and monitoring. However, with the sequencing of the human genome, rapid development of high-throughput approaches has allowed for a better understanding of the etiopathogenesis of complex diseases, including SLE. Here we present a review of the latest advancements in biomarker discovery during the “omics” era, using these novel technologies, for assisting in the diagnosis and prognosis of patients with SLE.

系统性红斑狼疮(SLE)是一种慢性自身免疫性炎症性疾病,其特点是自身抗体针对众多自核抗原。由于狼疮的异质性,识别便于诊断和监测的具有足够敏感性和特异性的标志物一直存在挑战。然而,人类基因组测序和高通量测序技术的快速发展有助于更好地理解复杂疾病(包括系统性红斑狼疮)的发病机制。本文介绍了“组学”时代采用新技术取得的生物标志物最新进展,以帮助SLE患者的诊断和预后。