文献简介

出版社:Clin Lab Med 37 (2017) 503–525

作  者:Vishwas Parekh, MD, John T. Seykora, MD, PhD

编  号:

关键字:Cutaneous Squamous Cell Carcinoma

年  份:2017   点击量:111

文献摘要 全文翻译

INTRODUCTION

简介

 

Epidemiology

流行病学

 

Nonmelanoma skin cancer is the most common malignancy worldwide. Historically, cutaneous squamous cell carcinoma (cSCC) has been thought to comprise about 20% of all nonmelanoma skin cancers, thus being the second most common malignancy after basal cell carcinoma (BCC), with a ratio of BCC to SCC estimated to be 4:1. However, recent data indicate that there is a significant shift underway in the relative proportion of nonmelanoma skin cancer, with the ratio of BCC to SCC found to be 1.0 in the US Medicare population. Several other studies bear out a trend for an increasing incidence of cSCC compared with BCC, particularly in the aging population. An accurate incidence of cSCC is not known because it is not required to be reported to national cancer registries; however, a metaanalysis of populationbased studies estimated that in 2012, 186,157 to 419,543 white individuals were diagnosed with cSCC in the United States alone. Note, these estimates do not include squamous cell carcinoma in situ (SCCIS), which likely occurs more frequently.

非黑色素瘤皮肤癌是世界上最常见的恶性肿瘤之一。历史上,皮肤鳞状细胞癌(cSCC)约占所有非黑色素瘤皮肤癌的20%,是仅次于基底细胞癌(BCC)的第二常见的恶性肿瘤,据推测BCC与 SCC的比值为4:1。然而,最近近期数据表明,非黑色素瘤皮肤癌的相对比例正发生显著变化,在美国医疗保险人群中,BCC与SCC比值为1。其他几项研究证实,相较于BCC,cSCC的发病率有增加趋势,尤其是在老年人群中。精确的cSCC发病率尚不知,因为它无需在国家癌症登记处报备;然而,一项基于人群的荟萃分析显示,2012年,仅在美国有186,157 到419,543的白人患者被诊断为cSCC。值得注意的是,这些数据不包括原位鳞状细胞癌(SCCIS),该病发病更频繁。