文献简介

出版社:国际皮肤性病学杂志

作  者:石海霞;张汝芝

编  号:

关键字:白癜风;自噬;黑素细胞;基因;维生素D

年  份:2017   点击量:346

文献摘要

AbstractAutophagy is a central cellular process of delivering organelles and cytoplasm to lysosomes for degradation and recycling of intracellular molecular components. Vitiligo is an acquired depigmented skin disease, characterized by loss or dysfunction of melanocytes in lesions. Vitiligo has a great impact on the quality of life of patients, and its pathogenesis is not yet clear. Studies have found that several mechanisms affect the occurrence and development of vitiligo, including the presence of ultraviolet radiation resistance-associated gene polymorphisms, autophagic degradation of melanosomes in keratinocytes, synergistic effects of autophagy pathway and oxidative stress, and regulation of the expression of microphthalmia transcription factor by microtubule-associated protein light chain 3. Recent studies have indicated that vitamin D could induce autophagy in a variety of cell types. The vitamin D derivative calcipotriol, which has been widely used in the topical treatment of vitiligo, can also induce autophagy of melanocytes. Therefore, researches on the relationship between autophagy and vitiligo are expected to provide new ideas for treating vitiligo.

【摘要】自噬是细胞的中枢性机制,运送细胞器和细胞质到溶酶体中降解,使分子成分再循环。白癜风是一种获得性色素脱失性皮肤病,以皮损内黑素细胞丢失或功能障碍为特征。白癜风对患者的生活质量造成很大影响,目前其发病机制尚未明确。经研究发现,抗紫外线相关基因的多态性、角质形成细胞中黑素小体的自噬降解、自噬途径和氧化应激的协同作用、微管相关蛋白轻链3调控小眼畸形相关转录因子表达等机制,影响白癜风的发生发展。最近的研究表明,维生素D可以诱导多种细胞类型自噬,目前广泛用于白癜风局部治疗的维生素D衍生物卡泊三醇,也能诱导黑素细胞自噬。因此自噬与白癜风关系的研究有望给白癜风的治疗提供新思路。