文献简介

出版社:

作  者:Aisha Lateef, MBBS, MRCP, MMed, FAMS, Michelle Petri, MD, MPH

编  号:

关键字:Systemic Lupus Erythematosus;Pregnancy

年  份:2017   点击量:66

文献摘要 全文翻译

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with a strong female predilection. Disease onset in a younger age group, coupled with improved survival, makes pregnancy a likely occurrence in the setting of SLE. Although outcomes have improved over time and successful live births can now be achieved in most cases, pregnancy still remains a high-risk situation in SLE. Both maternal and fetal mortality and morbidity are significantly increased, along with health care utilization and costs. A multidisciplinary coordinated approach with involvement of appropriate specialists and close monitoring is essential for optimal outcomes. This article discusses major issues and the management principles to guide clinicians caring for pregnant women with SLE.

系统性红斑狼疮(SLE)是一种多发于女性的累及多系统的自身免疫性疾病。该疾病好发于年轻患者,加上生存率提高,使SLE患者妊娠成为可能。虽然随着时间推移,治疗效果有所改善,且目前大多数患者可实现成功活产,但妊娠仍是系统性红斑狼疮患者高危情况。孕产妇和胎儿死亡率和发病率都显著增加,卫生保健利用率和成本随之增长。多学科协调处理、适当专家参与和密切监测对达到最佳治疗效果是必不可少的。本文讨论了系统性红斑狼疮患者妊娠期临床护理的主要问题和管理原则。