文献简介

出版社:JAMA Dermatology

作  者:Kaiane Habeshian, MD; Rana Hamdy, MD; Scott A. Norton, MD, MPH

编  号:

关键字:Mucormycosis

年  份:2017   点击量:111

文献摘要 全文翻译

A 4-year-old girl with newly diagnosed acute lymphocytic leukemia, receiving her initial course of chemotherapy with vincristine, daunorubicin, and methotrexate, developed a painful lesion on her left triceps. The tender area was beneath an adhesive bandage placed where she had received DTaP (diphtheria-tetanus-pertussis) and polio vaccinations 3 weeks earlier. Otherwise, she appeared remarkably well, and her vital signs were normal. Removing the bandage revealed a tender indurated gray-violet plaque (Figure, A). White blood cell and neutrophil counts were low at 0.4 K/μL (normal range,4.86-13.18K/μL) and 0.18 K/μL (normal range, 1.60-8.29 K/μL), respectively. Blood culture findings were negative. Punch biopsy specimens were obtained for histopathologic analysis (Figure, B) and fungal culture(Figure, C).

患者女性,4岁,新确诊为急性淋巴细胞性白血病,初期采用长春新碱、柔红霉素、氨甲喋呤化疗,左侧三头肌处出现疼痛皮损。3周前曾接受DTaP(白喉-破伤风-百日咳疫苗)和小儿麻痹症疫苗治疗的触痛区域下部采用绷带包扎。除此之外,患者表现良好,生命体征正常。去除绷带后出现一疼痛硬结性灰紫色斑块(图A)。白细胞和中性粒细胞计数分别低至0.4 k /μL(正常范围,4.86-13.18 k /μL)和0.18 K /μL(正常范围,1.60-8.29 K /μL)。血培养结果为阴性。取钻孔活检标本用于组织病理学分析(图B)和真菌培养(图C)。