文献简介

出版社:Am J Clin Dermatol

作  者:

编  号:

关键字:Alopecia Areata

年  份:2017   点击量:86

文献摘要 全文翻译

Abstract: Alopecia areata (AA) is non-scarring hair loss resulting from an autoimmune disorder. Severity varies from patchy hair loss that often spontaneously resolves to severe and chronic cases that can progress to total loss of scalp and body hair. Many treatments are available; however, the efficacy of these treatments has not been confirmed, especially in severe cases, and relapse rates are high. First-line treatment often includes corticosteroids such as intralesional or topical steroids for mild cases and systemic steroids or topical immunotherapy with diphenylcyclopropenone or squaric acid dibutylester in severe cases. Minoxidil and bimatoprost may also be recommended, usually in combination with another treatment. Ongoing research and new insights into mechanisms have led to proposals of innovative therapies. New directions include biologics targeting immune response as well as lasers and autologous platelet-rich plasma therapy. Preliminary data are encouraging, and it is hoped this research will translate into new options for the treatment of AA in the near future.

摘要:斑秃是一种因自身免疫性疾病引发的非瘢痕性脱发。其严重程度因斑状毛发脱失程度而异,通常自发消退,严重和慢性斑秃病例可发展为全秃和普秃。多种方法可用于治疗斑秃,但这些治疗方法的疗效尚未得到证实,特别是在严重病例中,复发率较高。一线治疗通常包括糖皮质激素治疗如注射或外用类固醇治疗轻度斑秃患者,系统性类固醇或局部免疫治疗(二苯环丙烯酮或方形酸二丁酯)严重斑秃患者。通常推荐米诺地尔和比马前列素与其他疗法联合使用。正在进行的研究和对机制的新见解提供了创新疗法。治疗新方向包括靶向免疫反应的生物制剂以及激光和自身富血小板血浆疗法。初步数据令人欢喜,希望这项研究能在不久的将来成为治疗斑秃的新选择。