文献简介

出版社:国际皮肤性病学杂志

作  者:马一平,林麟

编  号:

关键字:荨麻疹;组织胺类药;药理作用;治疗应用;安全

年  份:2017   点击量:26

文献摘要

【Abstract】Rupatadine, a new antihistamine with dual antagonistic activity against platelet-activating factor(PAF)and histamine H 1 receptors,can inhibit inflammatory reactions by affecting allergic reactions at different stages.It has a rapid onset of action and a long—lasting effect,so once—daily dosing is recommended. Clinical studies have shown that low—dose oral rupatadine can effectively control the symptoms of seasonal and perennial allergic rhinitis.Recent researches have demonstrated that it has good effect on some skin diseases such as chronic idiopathic urticaria and cold urticaria with good tolerability.

【摘要】卢帕他定是一种具有组胺H1受体和血小板活化因子受体双重拮抗作用的新型抗过敏药,能够作用于过敏反应发生的不同环节进而抑制炎症反应。卢帕他定起效快速、疗效持久,故而推荐每日一次口服。临床研究表明,卢帕他定低剂量口服能有效地控制季节性和常年过敏性鼻炎的症状。近年研究表明,其对慢性自发性荨麻疹、寒冷性荨麻疹等皮肤病亦有较好疗效,且耐受性好。