文献简介

出版社:国际皮肤性病学杂志

作  者:王小坡 ,陈浩, 姜祎群, 孙建方

编  号:

关键字:梅-罗综合征;肉芽肿病,口面部;病理学,临床;临床方案;回顾性研究

年  份:2015   点击量:39

提  供:本文由医客提供

文献摘要

目的 探讨肉芽肿性唇炎临床表现与组织病理学特点。方法 回顾分析2010---2014年 18例肉芽肿性唇炎患者临床及病理学资料。结果 肉芽肿性唇炎患者18例中,男9例,女9例,确诊时患者年龄3877岁,平均(552±112)岁;病程596个月,平均(205±227)个月;病程<111例,>1年 7例。18例患者均出现唇部复发性肿胀,皮疹触之有软橡皮感,无压痛。组织病理符合非干酪性坏死上皮细胞肉芽肿14例,非特异性炎症4例。1例拔除龋齿后皮损消退,9例患者使用泼尼松或加用羟氯喹治疗,其中6例皮损消退,3例疗效不佳。结论 肉芽肿性唇炎是一种不伴有其他体征或症状的独立口面肉芽肿疾病,需要临床结合组织病理检查进行诊断。

0bjective To assess the clinical and histopathologic characteristics of granulomatous cheilitis Methods Clinical and pathological data were collected from 18 patients with granulomatous cheilitis between 2010 and 2014and analyzed retrospectivelyResults Of the 18 patients9 were male and 9 were femaleThe age at final diagnosis ranged from 38 to 77 years(mean55.2±11.2 years)The clinical course was less than 1 year in 11 patientsmore than 1 year in 7 patientsand varied from 5 to 96 months(mean20.5±22.7months)All the patients presented with recurrent painless swelling of the lipswhich were rubbery on palpationHistopathological findings were consistent with non-ceaseous necrotic epithelioid cell granuloma in 14 casesand with nonspecific inflammation in 4 casesSkin lesions subsided in 1 patient after the removal of a decayed toothOf the 9 patients treated with oral prednisone alone or in combination with hydroxychloroquine6 experienced subsidence of lesionsbut 3 poorly responded. Conclusion Granulomatous cheilitis is an independent orofacial granulomatous disease without accompanying signs or symptomsand its diagnosis should be based on clinical and pathological presentations