文献简介

出版社:Journal of Immunology Research

作  者:Michelangelo Vestita,Angela Filoni

编  号:

关键字:

年  份:2015   点击量:311

文献摘要 全文翻译

Vitamin D features immunomodulatory effects on both the innate and adaptive immune systems, which may explain the growing evidence connecting vitamin D to allergic diseases. A wealth of studies describing a beneficial effect of vitamin D on atopic dermatitis (AD) prevalence and severity are known. However, observations linking high vitamin D levels to an increased risk of developing AD have also been published, effectively creating a controversy. In this paper, we review the existing literature on the association between AD and vitamin D levels, focusing on childhood. As of today, the role of vitamin D in AD is far from clear; additional studies are particularly needed in order to confirm the promising therapeutic role of vitamin D supplementation in childhood AD.

 

维生素D的免疫调节功能同时对先天性和适应性免疫系统的影响可解释维生素D与过敏性疾病的相关性。大量研究已证实维生素D对特应性皮炎(AD)的发病率和严重程度的有利作用。然而,因也有文章指出高水平维生素D可增加AD发病风险,从而引发了争议。本文综述了关于维生素D水平与AD(主要为儿童)相关的现有文献。迄今为止,维生素D在AD中的作用机制还不明确,尚需更多研究来证实补充维生素D对治疗儿童AD的前景。