文献简介

出版社:International Journal of Dermatology

作  者:Ines Zaraa, MD, Nadia Kerkeni, MD

编  号:

关键字:IgA pemphigus

年  份:2010   点击量:493

文献摘要

IgA pemphigus represents a group of autoimmune blistering skin diseases characterized by intraepidermal neutrophilic pustules, intercellular IgA antibodies, or circulating IgA antibodies to keratinocyte surfaces. Currently, it is seen as a distinct subset of pemphigus with particular clinical and immunopathologic pictures. As it is a newly defined disorder, its frequency is unknown but surely rare. Even less reported is the pemphigus with deposits of both IgG and IgA on keratinocyte cell surfaces; a new entity described in the recent literature as IgG and IgA pemphigus.

IgA天疱疮代表了一组自身免疫性水泡皮肤疾病,其特征为表皮内嗜中性脓疱,细胞间的IgA抗体,或角质形成细胞表面的循环IgA抗体。一般情况下,它被看作是具有特定临床和免疫病理图片的天疱疮的一个独特的子集。由于这是一个新定义的疾病,它的发病频率是未知的,但肯定罕见。甚至较少报道的是角质形成细胞的细胞表面有IgGIgA型两者的天疱疮沉积物;在最近的报道中,IgGIgA型天疱疮作为所描述的一个新的研究实体。

In this study, we report the first Tunisian case with IgG IgA pemphigus and try to discuss the clinical and immunopathological features of this new type of pemphigus.

在这项研究中,我们报道有关IgG/ IgA型天疱疮的第一个突尼斯病例并尝试探讨这种新型天疱疮的临床及免疫病理特点。