文献简介

出版社:The Korean Association of Oral and Maxillofacial Surgeons.

作  者:Da Jung Ryu, Sang Hoon Lee, Jong In Yuk

编  号:10.5125/jkaoms.2013.39.6.292

关键字:Verruciform xanthoma, Mouth, Foam cells, Immune mechanism

年  份:2013   点击量:467

文献摘要

Verruciform xanthoma (VX) is a rare, benign lesion that presents in the oral cavity, skin, or genital organs as a verrucous, papillomatous, or flat papule with varying colors. VX has indistinct clinical features, making histopathological examination necessary for a definitive diagnosis. Histologically, VX is characterized by parakeratosis, rete ridges with uniform depth, and an accumulation of the foam cells, which are also known as the “xanthoma cells”. These foam cells test positive for antibodies, such as CD-68 and vimentin; it is thought that VX foam cells are derived from the monocyte-macrophage lineage, and that VX’s pathogenic mechanism is partly related to an immune mechanism. Nevertheless, the pathogenesis of VX remains unclear. VX can be treated by surgical excision; other medical, chemical, and radiological treatments are not required postoperatively. Recurrence and malignant transformation of VX are rare. Two patients, each with a mass of unknown origin on the palatal gingiva, were presented at our clinic. Excisional biopsies of the masses were performed for a histological diagnosis after clinical and radiological examinations. Histological examination confirmed a diagnosis of VX in both cases. 

    疣状黄瘤(VX)是一种罕见的良性肿瘤,出现在口腔、皮肤或生殖器等处,呈疣状、乳头状或扁平状丘疹并伴有不同的颜色。VX临床特征很难辨认,要获得明确的诊断需要进行组织病理检查。组织学上,VX以角化不全,均匀深度的表皮突以及泡沫细胞(也被称为“黄瘤细胞”)的累积为特征。这些泡沫细胞抗体检测呈阳性,如CD-68和波形蛋白;人们认为VX泡沫细胞是从单核细胞 - 巨噬细胞系衍生而来的,并且VX的致病机理与免疫机理部分相关。然而,VX的发病机制尚不清楚。 可以通过手术切除对VX进行治疗;术后不需要其它的药物、化学和放射疗法进行治疗。VX复发和恶变是很罕见的。两名患者,在其腭侧牙龈处出现一个未知来源肿块,被送往我们医院进行治疗。临床和影像学检查后,我们进行肿块切除活检,以便于组织病理学的诊断。在这两则病例中,组织学检查证实了VX的诊断。